Your Drug Options for IV Dental Sedation
January 13, 2025

Have you ever wondered what specific drugs dentists use for IV sedation? While many different chemicals can relieve anxiety and dull pain, no two solutions are exactly the same. Each can affect your body differently and have varying windows of effectiveness.
If you’d like to learn more about your options for IV sedation, just keep reading!
1. Midazolam
Like Xanax and Valium, midazolam is derived from benzodiazepines. This class of drugs is typically prescribed to treat anxiety, insomnia, and seizures, so you can rest assured that midazolam is effective as a calming agent. It can also relax your muscles and induce temporary memory loss – which simply means you likely won’t remember your treatment.
Midazolam has minimal interference with your heart and lungs, and the FDA approves of its use for both adults and children. It’s quite safe but can last for up to two hours after injection, so it’s a good idea to arrange for reliable transportation if your IV sedation involves midazolam.
2. Propofol
This drug is interesting because it contains soybean oil, glycerol, and egg lecithin, which can make it uncomfortable when administered intravenously. To counteract this, propofol is usually mixed with an anesthetic.
Propofol takes effect in seconds and fades almost as quickly. It is an effective sedative, though, so professionals administer it throughout the duration of treatment. They also monitor patients closely, as the drug can lower blood pressure. But as long as you’re not allergic to egg or soy, Propofol is considered safe for adults and children.
3. Ketamine
Ketamine is derived from a psychedelic, so you know it’s powerful! When administered intravenously by a qualified medical professional, ketamine relieves pain and blurs memory of treatment. All the while, your breathing and cardiovascular system will be able to cycle as normal.
One dose of ketamine will keep you calm and relaxed for about five to ten minutes, so it’s usually used for shorter treatments. Unlike the previous two drugs, ketamine isn’t recommended for children, but can be an effective solution for adults.
4. Dexmedetomidine
Although you’ll still be able to communicate with your dentist, dexmedetomidine mimics your body’s sleep patterns. It needs to be administered continuously, and will keep you lulled into a comfortable drowsiness for the duration of your treatment.
Dexmedetomidine is given in low doses because it can affect breathing and heart rate. Patients with diabetes, chronic high blood pressure, or who are over the age of 65 are advised to consider dexmedetomidine carefully and to consider a milder alternative.
Talk to Your Dentist for Safe Treatment
IV dental sedation is a safe accommodation for nervous patients, but you should still discuss your health history and drug options with your dentist! Communicate with them clearly and honestly, and they’ll help you choose the best IV sedation solution for you.
About the Author
Dr. Andrew Barnett is a board certified periodontist who believes every patient deserves a unique treatment plan that suits their needs. He knows IV sedation can be a life-changing accommodation for nervous or uncomfortable patients, and is committed to making sure its administered as safely as possible. If you’re looking for a dentist who will help you have a positive treatment experience, contact Dr. Barnett’s office at 214-691-2614.
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